Exceptional Human Longevity
نویسندگان
چکیده
منابع مشابه
Search for mechanisms of exceptional human longevity.
This study presents initial findings of a new ongoing research project aimed to identify important predictors and mechanisms of exceptional human longevity. For this purpose the detailed data on long-lived people surviving to 100 years in the Unites States are collected, validated, and analyzed. The study found that being born to a young mother is an important predictor of person's longevity. T...
متن کاملChildhood Conditions and Exceptional Longevity
A number of previous studies found interesting links between the early-life experiences and a subsequent mortality in later life. Such findings justify further advancement of these studies by exploring possible links between childhood conditions and exceptional longevity (survival to 100 years). However a number of methodological issues have to be resolved (such as data availability, quality, a...
متن کاملDeterminants of exceptional human longevity: new ideas and findings.
Studies of centenarians are useful in identifying factors leading to long life and avoidance of fatal diseases. In this article we consider several approaches to study effects of early-life and midlife conditions on survival to advanced ages: use of non-biological relatives as controls, the within-family analysis, as well as a sampling of controls from the same population universe as centenaria...
متن کاملMeta-analysis of genetic variants associated with human exceptional longevity
Despite evidence from family studies that there is a strong genetic influence upon exceptional longevity, relatively few genetic variants have been associated with this trait. One reason could be that many genes individually have such weak effects that they cannot meet standard thresholds of genome wide significance, but as a group in specific combinations of genetic variations, they can have a...
متن کاملBiodemography of exceptional longevity: early-life and mid-life predictors of human longevity.
This study explores the effects of early-life and middle-life conditions on exceptional longevity using two matched case-control studies. The first study compares 198 validated centenarians born in the United States between 1890 and 1893 to their shorter-lived siblings. Family histories of centenarians were reconstructed and exceptional longevity validated using early U.S. censuses, the Social ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Mayo Clinic Proceedings
سال: 2019
ISSN: 0025-6196
DOI: 10.1016/j.mayocp.2018.10.005